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Inheritance


People are born with an inherited bleeding disorder. They cannot catch it from someone like a cold. A bleeding disorder is usually passed down from parent to child at conception. The disorder is caused by an abnormal gene. Genes carry messages about the way the body’s cells will develop as a baby grows into an adult. They determine a person’s hair and eye colour, for example. Sometimes a bleeding disorder can occur when there is no family history of it. This is called a spontaneous mutation. It was caused by a change in the person’s own genes.

Von Willebrand disease

All types of VWD are inherited in an autosomal pattern. This means that men and women are affected in equal numbers. (See Heredity of von Willebrand disease).

Platelet function disorders

Platelet function disorders have variable inheritance patterns. Some follow an autosomal recessive pattern of inheritance. This means that both parents need to carry the defective gene for the child to be affected. Others follow an autosomal dominant pattern, meaning only one of the parents needs to carry the gene for it to be passed on to the child. Platelet function disorders affect men and women in equal numbers. (See How are congenital platelet function disorders passed on?)

Hemophilia A and B

The genes for hemophilia A and B are on the X chromosome. For this reason, hemophilia is called an X-linked (or sex-linked) disorder. (See Heredity of hemophilia)

Other factor deficiencies

All of the other factor deficiencies are inherited in an autosomal recessive pattern. Both parents need to be carriers of the gene to pass on the severe form of the disorder to their children. Men and women are affected in equal numbers.

(See Transmission of factor 1, fibrinogen deficiency)
(See How is factor II deficiency inherited?)
(See How factor V deficiency is inherited)
(See How factor VII deficiency is inherited)
(See How is factor X deficiency inherited?)
(See Transmission of factor XI deficiency)
(See How factor XII deficiency is inherited)
(See How factor XIII deficiency is inherited)