A small number of Canadians, fewer than 1,000, suffer from rare factor deficiencies. These people have low levels of a specific blood protein, either factor I, II, V, VII, X, XI or XIII. Like hemophilia and VWD, these are genetic conditions for which there are treatments but no cures.


Factor I fibrinogen 1 in 1,000,000           Usually mild, except with complete absence of fibrinogen
Factor II prothrombin 1 in 1,000,000 Usually mild
Factor V parahemophilia 1 in 1,000,000 Usually mild
Combined F V and F VIII           1 in 1,000,000 Usually mild
Factor VII Alexander’s 1 in 1,000,000 Severe when Factor VII levels are low
Factor VIII Hemophilia 1 in 10,000 Severe when Factor VIII levels are below 1%
Factor IX Hemophilia B 1 in 50,000 Severe when Factor IX levels are below 1%
Factor X Stuart-Prower 1 in 500,000 Moderate to severe when Factor X levels are below 10%
Factor XI Hemophilia C 1 in 100,000 Mild to moderate when Factor XI levels are below 15%
Factor XIII   1 in 3,000,000 Severe